Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi
Date
2013
Authors
Chooi, Yit-Heng
Fang, Jinxu
Liu, Hong
Filler, Scott G
Wang, Pin
Tang, Yi
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Volume Title
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American Chemical Society
Abstract
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC 50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
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Keywords
Keywords: dimethylallyltransferase; immunosuppressive agent; polyketide; animal; article; Aspergillus fumigatus; chemistry; conformation; drug effect; enzymology; fungus; genetics; genome; HeLa cell; human; isolation and purification; macrophage; metabolism; mouse;
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Organic Letters
Type
Journal article
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2037-12-31
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