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Structure-activity delineation of quinones related to the biologically active Calothrixin B

Date

Authors

Bernardo, Paul

Chai, Christina

Le Guen, Maurice

Smith, Geoffrey D

Waring, Paul

Publisher

Pergamon-Elsevier Ltd

Abstract

Quinones such as Calothrixins A and B display a range of biological properties. As part of our ongoing studies to elucidate the mechanism of action of the Calothrixins, several related quinones were synthesized and tested for biological activity. The results of the structure-activity relationship (SAR) studies are reported here.

Keywords

Keywords: 2 methylcarbazoledione; benzocarbazoledione; calothrixin a; calothrixin B; carbazole 1,4 dione; carbazole derivative; indolophenanthrene 7,13 dione; isoquinoline 5,8 dione; murrayaquinone a; quinone derivative; animal cell; antimalarial activity; antineop SAR

URI

http://hdl.handle.net/1885/23878

Collections

ANU Research Publications

Source

Bioorganic and Medicinal Chemistry Letters

Type

Journal article

DOI

10.1016/j.bmcl.2006.09.090

Restricted until

2037-12-31

Downloads

File

Description

01_Bernardo_Structure-activity_delineation_2007.pdf (138.83 KB)