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Glycosaminoglycan-induced activation of the β-secretase (BACE1) of Alzheimer's disease

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Date

2010

Authors

Klaver, David W.
Wilce, Matthew C.J.
Gasperini, Robert
Freeman, Craig
Juliano, John Paul
Foa, Lisa
Aguilar, Marie-Isabel
Small, David H
Parish, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Blackwell Publishing Ltd

Abstract

The β-site APP cleaving enzyme (BACE1) is responsible for the first step in the production of the β-amyloid protein of Alzheimer's disease. BACE1 is synthesized as a partially active zymogen (proBACE1). We previously showed that the glycosaminoglycan (G

Description

Keywords

Keywords: beta secretase; beta secretase 1; chondroitin sulfate; enzyme precursor; fucoidin; glycosaminoglycan; heparan sulfate; heparin; low molecular weight heparin; pentosan polysulfate; pepsinogen; polyglutamic acid; polysialic acid; Alzheimer disease; article; ß-secretase; Alzheimer's disease; Amyloid; Glycosaminoglycan; Heparin; Protease

Citation

URI

http://hdl.handle.net/1885/28577

Collections

ANU Research Publications

Source

Journal of Neurochemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1111/j.1471-4159.2010.06571.x

Restricted until

2037-12-31

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01_Klaver_Glycosaminoglycan-induced_2010.pdf (600.41 KB)

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