Frequency of Cancer Genes on the Chicken Z Chromosome and its Human Homologues: Implications for Sex Chromosome Evolution
Date
2007
Authors
Stiglec, Rami
Kohn, Matthias
Fong, James
Ezaz, Tariq
Hameister, Horst
Graves, Jennifer
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Wiley-VCH Verlag GMBH
Abstract
It has been suggested that there are special evolutionary forces that act on sex chromosomes. Hemizygosity of the X chromosome in male mammals has led to selection for male-advantage genes, and against genes posing extreme risks of tumor development. A similar bias against cancer genes should also apply to the Z chromosome that is present as a single copy in female birds. Using comparative database analysis, we found that there was no significant underrepresentation of cancer genes on the chicken Z, nor on the Z-orthologous regions of human chromosomes 5 and 9. This result does not support the hypothesis that genes involved in cancer are selected against on the sex chromosomes.
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Keywords: APC protein; fibroblast growth factor 1; fibroblast growth factor 18; fibroblast growth factor receptor 4; glial cell line derived neurotrophic factor; granulocyte macrophage colony stimulating factor; histone deacetylase 3; interferon regulatory factor 1
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Source
Comparative and Functional Genomics
Type
Journal article
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2037-12-31
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