Preparation of magnetic and bioactive calcium zinc iron silicon oxide composite for hyperthermia treatment of bone cancer and repair of bone defects

Date

2011

Authors

Jiang, Yuming
Ou, Jun
Zhang, Zhanhe
Qin, Qing Hua

Journal Title

Journal ISSN

Volume Title

Publisher

Kluwer Academic Publishers

Abstract

In this paper, a calcium zinc iron silicon oxide composite (CZIS) was prepared using the sol-gel method. X-ray diffraction (XRD) was then employed to test the CZIS composite. The results from the test showed that the CZIS had three prominent crystalline phases: Ca2Fe1.7Zn0.15Si0.15O5, Ca2SiO4, and ZnFe2O4. Calorimetric measurements were then performed using a magnetic induction furnace. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analysis were conducted to confirm the growth of a precipitated hydroxyapatite phase after immersion in simulated body fluid (SBF). Cell culture experiments were also carried out, showing that the CZIS composite more visibly promoted osteoblast proliferation than ZnFe2O4 glass ceramic and HA, and osteoblasts adhered and spread well on the surfaces of composite samples.

Description

Keywords

Keywords: Bone cancer; Bone defect; Calcium-zinc; Calorimetric measurements; Composite samples; Crystalline phasis; Osteoblast proliferation; Oxide composites; Simulated body fluids; Bone; Calcium; Cell culture; Energy dispersive spectroscopy; Glass ceramics; Hydro

Citation

Source

Journal of Materials Science - Materials in Medicine

Type

Journal article

Book Title

Entity type

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License Rights

DOI

10.1007/s10856-010-4225-z

Restricted until

2037-12-31