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The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina

Fernando, Nilisha; Natoli, Riccardo; Valter, Krisztina; Provis, Jan; Rutar, Matt


Background The activity of macrophages is implicated in the progression of retinal pathologies such as atrophic age-related macular degeneration (AMD), where they accumulate among the photoreceptor layer and subretinal space. This process is aided by the local expression of chemokines, which furnish these cells with directional cues that augment their migration to areas of retinal injury. While these qualities make chemokines a potential therapeutic target in curtailing...[Show more]

CollectionsANU Research Publications
Date published: 2016-02-24
Type: Journal article
Source: Journal of Neuroinflammation
DOI: 10.1186/s12974-016-0514-x
Access Rights: Open Access


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