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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Sasaki, Masato; Knobbe-Thomson, C. B; Munger, J. C; Lind, E. F; Brenner, Dirk; Bruestle, Anne; Harris, Isaac S; Holmes, R; Wakeham, Andrew; Haight, J; You-Ten, A; Li, Wanda Y; Schalm, S; Su, S. M; Virtanen, C; Reifenberger, Guido; Ohashi, Pamela; Barber, Dwayne L; Figueroa, Maria E; Melnick, Ari; Zuniga-Pflucker, Juan-Carlos; Mak, Tak W

Description

Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently found in human glioblastomas1 and cytogenetically normal acute myeloid leukaemias (AML). These alterations are gain-of-function mutations in that they drive the synthesis of the ‘oncometabolite’ R-2-hydroxyglutarate (2HG)3 . It remains unclear howIDH1 and IDH2 mutations modify myeloid cell development and promote leukaemogenesis. Here we report the characterization of conditional knock-in (KI) mice in which...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/98986
Source: Nature
DOI: 10.1038/nature11323

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