Testosterone regulation of cyclin E kinase is a key factor determining gender differences in hepatocarcinogenesis
Background & Aim: While gender differences in hepatocellular carcinoma (HCC) are profound, the mechanism is unclear. Using castration and hormone replacement strategies, we tested whether these gender differences are attributable to testosterone or estradiol/progesterone (E/P) effects on cell cycle regulators and p53. Methods: We studied dysplastic liver and HCCs in intact and castrated diethylnitrosamine (DEN)-injected C57BL/6J male and female mice, with or without hormonal replacement....[Show more]
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|Source:||Journal of Gastroenterology and Hepatology|
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