Structure of the RTP-DNA complex and the mechanism of polar replication fork arrest
The coordinated termination of DNA replication is an important step in the life cycle of bacteria with circular chromosomes, but has only been defined at a molecular level in two systems to date. Here we report the structure of an engineered replication terminator protein (RTP) ot Bacillus subtilis in complex with a 21 base pair DNA by X-ray crystallography at 2.5 Å resolution. We also use NMR spectroscopic titration techniques. This work reveals a novel DNA interaction involving a dimeric...[Show more]
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|Source:||Nature Structural Biology|
|01_Wilce_Structure_of_the_RTP-DNA_2001.pdf||3.81 MB||Adobe PDF||Request a copy|
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