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The global spike: Conserved dendritic properties enable unique ca2+ spike generation in low-threshold spiking neurons

Connelly, William; Crunelli, Vincenzo; Errington, Adam

Description

Low-threshold Ca2 spikes (LTS) are an indispensible signaling mechanism for neurons in areas including the cortex, cerebellum, basal ganglia, and thalamus. They have critical physiological roles and have been strongly associated with disorders including epilepsy, Parkinson’s disease, and schizophrenia. However, although dendritic T type Ca2 channels have been implicated in LTS generation, because the properties of low-threshold spiking neuron dendrites are unknown, the precise mechanism has...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98831
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.2740-15.2015
Access Rights: Open Access

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