Dau, Xuan Duc; Willis, Anthony; Pyne, Stephen G
The diastereoselective synthesis of the A-B-C tricyclic ring structure of the Stemona alkaloid stemocurtisine is described. This tricyclic precursor to the natural product was obtained in 19 steps from a known vinyl iodide. Attempts to prepare the C-3a-C-11 ether moiety of this alkaloid through a photochemically induced oxidative cyclization method were unsuccessful because of the cleavage of the A-ring.
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.