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Abnormal electrophysiological motor responses in Huntington's disease: Evidence of premanifest compensation

Turner, Lauren; Croft, Rodney; Churchyard, Andrew; Looi, Jeffrey; Apthorp, Deborah; Georgiou-Karistianis, Nellie

Description

Background: Huntington's disease (HD) causes progressive motor dysfunction through characteristic atrophy. Changes to neural structure begin in premanifest stages yet individuals are able to maintain a high degree of function, suggesting involvement of supportive processing during motor performance. Electroencephalography (EEG) enables the investigation of subtle impairments at the neuronal level, and possible compensatory strategies, by examining differential activation patterns. We aimed to...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98689
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0138563

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