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Providing a molecular mechanism for P-glycoprotein; Why would i bother?

Callaghan, Richard


It is almost 40 years since the drug efflux pump P-glycoprotein (permeability glycoprotein or P-gp) was shown to confer multi-drug resistance in cancer cells. This protein has been one of the most extensively investigated transport proteins due to its intriguing mechanism and its affect in oncology. P-gp is known to interact with over 300 compounds and the ability to achieve this has not yet been revealed. Following the binding of substrate and nucleotide, a complex series of conformational...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Biochemical Society Transactions
DOI: 10.1042/BST20150131


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