Xin, Gang; Schauder, David M.; Lainez, Begona; Weinstein, Jason S.; Dai, Zhengxi; Chen, Yuhong; Esplugues, Ennric; Wen, Renren; Wang, Demin; Parish, Ian; Zajac, Allan J.; Craft, Joe; Cui, Weiguo
Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the CD8 T cell response; however, the molecular pathways by which IL-21 sustains CD8 T cell immunity remain unclear. We demonstrate that IL-21 causes a phenotypic switch of transcription factor expression in CD8 T cells during chronic viral infection characterized by sustained BATF expression. Importantly, BATF expression during chronic...[Show more]
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