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Sizing up the key determinants of the CD8+ T cell response

Tscharke, David; Croft, Nathan P; Doherty, Peter; La Gruta, Nicole L

Description

Naive CD8 + T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective eradication of viruses and tumours. Although the past decades have seen enormous advances in cellular immunology, a precise understanding of the key elements that determine the specificity and magnitude of primary CTL responses has been lacking. However, recent technological advances have allowed us to more accurately identify, characterize and quantitate key determinants that define the specificity and...[Show more]

dc.contributor.authorTscharke, David
dc.contributor.authorCroft, Nathan P
dc.contributor.authorDoherty, Peter
dc.contributor.authorLa Gruta, Nicole L
dc.date.accessioned2016-02-24T22:41:22Z
dc.identifier.issn1474-1733
dc.identifier.urihttp://hdl.handle.net/1885/98656
dc.description.abstractNaive CD8 + T cells give rise to cytotoxic T lymphocytes (CTLs), which promote the effective eradication of viruses and tumours. Although the past decades have seen enormous advances in cellular immunology, a precise understanding of the key elements that determine the specificity and magnitude of primary CTL responses has been lacking. However, recent technological advances have allowed us to more accurately identify, characterize and quantitate key determinants that define the specificity and magnitude of CD8 + T cell-mediated immunity. This Review discusses the technical and conceptual advances that have markedly changed our understanding of the determinants of primary CTL responses.
dc.publisherNature Publishing Group
dc.sourceNature Reviews Immunology
dc.titleSizing up the key determinants of the CD8+ T cell response
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume15
dc.date.issued2015
local.identifier.absfor060500 - MICROBIOLOGY
local.identifier.absfor110700 - IMMUNOLOGY
local.identifier.ariespublicationU3488905xPUB6669
local.type.statusPublished Version
local.contributor.affiliationTscharke, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCroft, Nathan P, Monash University
local.contributor.affiliationDoherty, Peter, University of Melbourne
local.contributor.affiliationLa Gruta, Nicole L, University of Melbourne
local.description.embargo2037-12-31
local.bibliographicCitation.issue11
local.bibliographicCitation.startpage705
local.bibliographicCitation.lastpage716
local.identifier.doi10.1038/nri3905
dc.date.updated2016-02-24T10:11:23Z
local.identifier.scopusID2-s2.0-84945457742
CollectionsANU Research Publications

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