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Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease

Wang, Ting-Yi; Bruggeman, Kiara; Kauhausen, Jessica A; Rodriguez, Alexandra; Nisbet, David; Parish, Clare L.

Description

With the brain's limited capacity for repair there is a need for new and innovative therapies to promote regeneration. Stem/progenitor cell transplantation has received increasing attention, and whilst clinical trials demonstrating functional integration exist, inherent variability between patients has hindered development of this therapy. Variable outcomes have largely been attributed to poor survival and insufficient reinnervation of target tissues due in part to the suboptimal host...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/98627
Source: Biomaterials
DOI: 10.1016/j.biomaterials.2015.09.039

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