Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
Bothur, E; Raifer, H; Haftmann, Claudia; Stittrich, Anna-Barbara; Bruestle, Anne; Brenner, Dirk; Bollig, Nadine; Bieringer, Maria; Kang, Chol-Ho; Reinhard, Katharina; Camara, B; Huber, Magdalena; Visekruna, Alexander; Steinhoff, Ulrich
Regulatory T-cells induced via IL-2 and TGF in vitro (iTreg) suppress immune cells and are potential therapeutics during autoimmunity. However, several reports described their re-differentiation into pathogenic cells in vivo and loss of their key functional transcription factor (TF) FOXP3 after T-cell antigen receptor (TCR)-signalling in vitro. Here, we show that TCR-activation antagonizes two necessary TFs for foxp3 gene transcription, which are themselves regulated by phosphorylation....[Show more]
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