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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

Pulcini, Serena; Staines, Henry M; Lee, Andrew H; Shafik, Sarah; Bouyer, Guilherme; Moore, Catherine M; Daley, Daniel A.; Hoke, Matthew J.; Altenhofen, Lindsey M.; Painter, Heather J.; Mu, Jianbing; Ferguson, David J.P.; Llinas, Manuel; Martin, Rowena; Fidock, David A; Cooper, Ronald A.; Krishna, Sanjeev

Description

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P. falciparum lines subjected to selection by amantadine or blasticidin that carry PfCRT mutations (C101F or L272F), causing the development of enlarged food vacuoles. These parasites also have increased sensitivity to chloroquine and some other quinoline antimalarials, but exhibit no or minimal change in...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98589
Source: Scientific Reports
DOI: 10.1038/srep14552
Access Rights: Open Access

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