Skip navigation
Skip navigation

Risk factors for pertussis hospitalizations in Australians aged 45 years and over: A population based nested case-control study

Karki, Surendra; McIntyre, Peter; Newall, Anthony T; MacIntyre, C. Raina; Banks, Emily; Liu, Bette

Description

Although studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 and Up prospective cohort in New South Wales, Australia, with an incident pertussis diagnosis during 2006-2012. Cases were defined as those with a hospitalization coded as...[Show more]

dc.contributor.authorKarki, Surendra
dc.contributor.authorMcIntyre, Peter
dc.contributor.authorNewall, Anthony T
dc.contributor.authorMacIntyre, C. Raina
dc.contributor.authorBanks, Emily
dc.contributor.authorLiu, Bette
dc.date.accessioned2016-02-24T22:41:06Z
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/1885/98566
dc.description.abstractAlthough studies have described factors associated with pertussis hospitalization in children, data on adult hospitalization are sparse. We examined the association between patient characteristics and hospitalization among older adults with pertussis. We conducted a nested case-control study of participants in the 45 and Up prospective cohort in New South Wales, Australia, with an incident pertussis diagnosis during 2006-2012. Cases were defined as those with a hospitalization coded as 'whooping cough' or 'non-specific respiratory disease/cough' between a week prior and 6 weeks after the diagnosis of pertussis based on laboratory tests. Controls were participants diagnosed with pertussis but not hospitalized. Among 265,287 participants, the incidence of pertussis and pertussis hospitalization was 83.9 (95% [confidence interval] CI, 78.7-89.6) and 2.9 (95% CI, 2.1-4.1)/100,000 person-years, respectively. Among 33 cases and 882 controls, factors associated with hospitalization were increasing age (compared to those 45-54 years, adjusted odds ratio [aOR] 5.4 (95% CI, 1.6-18.2) and 8.9 (95% CI, 2.3-34.7) in those aged 65-74 years and 75+ years, respectively) and smoking (ever versus never, aOR 2.37 (95% CI, 1.11-5.06)). The risk of pertussis hospitalization is substantially higher in ≥65 years old. A booster dose of diphtheria-tetanus-pertussis vaccine could be readily integrated into routine vaccination for this age group.
dc.publisherElsevier
dc.sourceVaccine
dc.titleRisk factors for pertussis hospitalizations in Australians aged 45 years and over: A population based nested case-control study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume33
dc.date.issued2015
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.ariespublicationU3488905xPUB6051
local.type.statusPublished Version
local.contributor.affiliationKarki, Surendra, University of New South Wales
local.contributor.affiliationMcIntyre, Peter, The National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases
local.contributor.affiliationNewall, Anthony T, University of New South Wales
local.contributor.affiliationMacIntyre, C. Raina, University of New South Wales
local.contributor.affiliationBanks, Emily, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLiu, Bette, The Sax Institute
local.description.embargo2037-12-31
local.bibliographicCitation.issue42
local.bibliographicCitation.startpage5647
local.bibliographicCitation.lastpage5653
local.identifier.doi10.1016/j.vaccine.2015.08.068
dc.date.updated2016-02-24T10:09:29Z
local.identifier.scopusID2-s2.0-84943455250
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Karki_Risk_factors_for_pertussis_2015.pdf532.3 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator