Skip navigation
Skip navigation

A cascade synthetic route to new bioactive spiroindolinepyrido[1,2-a]indolediones from indirubin

Sele, Alexander M.; Bremner, John B; Willis, Anthony; Haritakun, Rachada; Griffith, Renate; Keller, Paul

Description

The allylation of indirubin produced the expected indolic N′-allylindirubin and N,N′-diallylindirubin derivatives in moderate yields, together with the corresponding N-substituted isatin products. At higher temperatures, the base-initiated reaction with allylic halides yielded spiroindolinepyrido[1,2-a]indolediones in a one-pot cascade reaction sequence with yields of up to 70%. These readily accessed, new spiro compounds represent the first reported examples of indirubin participating in...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98561
Source: Tetrahedron
DOI: 10.1016/j.tet.2015.08.012

Download

File Description SizeFormat Image
01_Sele_A_cascade_synthetic_route_to_2015.pdf908 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator