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Design of Redox/Radical Sensing Molecules via Nitrile Imine-Mediated Tetrazole-ene Cycloaddition (NITEC)

Lederhose, Paul; Haworth, Naomi; Thomas, Komba; Bottle, Steven E; Coote, Michelle; Barner-Kowollik, Christopher; Blinco, James P.


The current study introduces a novel synthetic avenue for the preparation of profluorescent nitroxides via nitrile imine-mediated tetrazole-ene cycloaddition (NITEC). The photoinduced cycloaddition was performed under metal-free, mild conditions allowing the preparation of a library of the nitroxide functionalized pyrazolines and corresponding methoxyamines. High reaction rates and full conversion were observed, with the presence of the nitroxide having no significant impact on the...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b01088


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