Skip navigation
Skip navigation

Glucocorticoids improve erythroid progenitor maintenance and dampen Trp53 response in a mouse model of Diamond-Blackfan anaemia

Sjogren, Sara E.; Siva, Kavitha; Soneji, Shamit; George, Amee; Winkler, Marcus; Jaako, Pekka; Wlodarski, Marcin; Karlsson, Stefan; Hannan, Ross; Flygare, Johan


Diamond-Blackfan anaemia (DBA) is a rare congenital disease causing severe anaemia and progressive bone marrow failure. The majority of patients carry mutations in ribosomal proteins, which leads to depletion of erythroid progenitors in the bone marrow. As many as 40% of all DBA patients receive glucocorticoids to alleviate their anaemia. However, despite their use in DBA treatment for more than half a century, the therapeutic mechanisms of glucocorticoids remain largely unknown. Therefore we...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: British Journal of Haematology
DOI: 10.1111/bjh.13632


File Description SizeFormat Image
01_Sjogren_Glucocorticoids_improve_2015.pdf1.2 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator