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The membrane-active amphibian peptide caerin 1.8 inhibits fibril formation of amyloid ?1-42

Liu, Yanqin; Wang, Tianfang; Calabrese, Antonio N.; Carver, John; Cummins, Scott F.; Bowie, John H.

Description

The amphibian host-defense peptide caerin 1.8 [1GLFKVLGSV10AKHLLPHVVP20VIAEKL(NH<inf>2</inf>)] inhibits fibril formation of amyloid β 1-42 [1DAEFRHDSG10YEVHHQKLVF20FAEDVGSNKG30AIIGLMVGGV40VIA] [Aβ42] (the major precursor of the extracellular fibrillar deposits of Alzheimer's disease). Some truncated forms of caerin 1.8 also inhibit fibril formation of Aβ42. For example, caerin 1.8 (1-13) [1GLFKVLGSV10AKHL(NH<inf>2</inf>) and caerin 1.8 (22-25) [KVLGSV10AKHLLPHVVP20VIAEKL(NH<inf>2</inf>)] show...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98504
Source: Peptides
DOI: 10.1016/j.peptides.2015.08.004

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