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The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells

Griffiths, Kristin; Ji, Jing; Milburn, Peter J; Hirst, Timothy; O'Neill, Helen


Escherichia coli's heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen. Here, we investigate the direct effect of intravenously administered EtxB on the size of the dendritic and myeloid cell populations in spleen. EtxB treatment appears to enhance the development and turnover of dendritic and myeloid cells from precursors within the spleen. EtxB treatment also gives a dendritic...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Cellular and Molecular Medicine
DOI: 10.1111/jcmm.12599
Access Rights: Open Access


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