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Mechanism of Ion Permeation and Selectivity in a Voltage Gated Sodium Channel

Corry, Ben; Thomas, Michael


The rapid and selective transport of Na+ through sodium channels is essential for initiating action potentials within excitable cells. However, an understanding of how these channels discriminate between different ion types and how ions permeate the pore has remained elusive. Using the recently published crystal structure of a prokaryotic sodium channel from Arcobacter butzleri, we are able to determine the steps involved in ion transport and to pinpoint the location and likely mechanism used...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of the American Chemical Society
DOI: 10.1021/ja210020h


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