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Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

Bahlo, Melanie; Booth, David; Broadley, Simon A; Brown, Matthew A; Foote, Simon; Griffiths, Lyn; Kilpatrick, Trevor J; Lechner-Scott, Jeanette; Moscato, Pablo Alberto; Perreau, Victoria M; Rubio, Justin P; Scott, Rodney; Stankovich, Jim; Stewart, Graeme; Taylor, Bruce; Wiley, James; Clarke, Gynnis; Cox, Mathew B; Csurhes, P A; Danoy, Patrick; Drysdale, Karen; Field, Judith; Greer, Judith M; Guru, Preethi; Hadler, Johanna S; McMorran, Brendan; Jensen, Cathy J

Description

To identify multiple sclerosis (MS) susceptibility loci, we conducted a genome-wide association study (GWAS) in 1,618 cases and used shared data for 3,413 controls. We performed replication in an independent set of 2,256 cases and 2,310 controls, for a total of 3,874 cases and 5,723 controls. We identified risk-associated SNPs on chromosome 12q13-14 (rs703842, P = 5.4 × 10 11; rs10876994, P = 2.7 × 10 10; rs12368653, P = 1.0 × 10 7) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 ×...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/98414
Source: Nature Genetics
DOI: 10.1038/ng.396

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