Skip navigation
Skip navigation

Platelets kill intraerythrocytic malarial parasites and mediate survival to infection

McMorran, Brendan; Marshall, Vikki M; de Graaf, Carolyn; Drysdale, Karen; Shabbar, Meriam; Smyth, Gordon K.; Corbin, Jason E; Alexander, Warren S; Foote, Simon


Platelets play a critical role in the pathogenesis of malarial infections by encouraging the sequestration of infected red blood cells within the cerebral vasculature. But platelets also have well-established roles in innate protection against microbial infections. We found that purified human platelets killed Plasmodium falciparum parasites cultured in red blood cells. Inhibition of platelet function by aspirin and other platelet inhibitors abrogated the lethal effect human platelets exert on...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Science
DOI: 10.1126/science.1166296


File Description SizeFormat Image
01_McMorran_Platelets_kill_2009.pdf232.03 kBAdobe PDF    Request a copy
02_McMorran_Platelets_kill_2009.pdf278.17 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator