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Platelets kill intraerythrocytic malarial parasites and mediate survival to infection

McMorran, Brendan; Marshall, Vikki M; de Graaf, Carolyn; Drysdale, Karen; Shabbar, Meriam; Smyth, Gordon K.; Corbin, Jason E; Alexander, Warren S; Foote, Simon

Description

Platelets play a critical role in the pathogenesis of malarial infections by encouraging the sequestration of infected red blood cells within the cerebral vasculature. But platelets also have well-established roles in innate protection against microbial infections. We found that purified human platelets killed Plasmodium falciparum parasites cultured in red blood cells. Inhibition of platelet function by aspirin and other platelet inhibitors abrogated the lethal effect human platelets exert on...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/98413
Source: Science
DOI: 10.1126/science.1166296
Access Rights: Open Access

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