Platelet factor 4 and duffy antigen required for platelet killing of Plasmodium falciparum
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McMorran, Brendan; Wieczorski, Laura; Drysdale, Karen; Chan, Jo-Anne; Huang, Hong Ming; Smith, Clare; Mitiku, Chalachew; Beeson, James G; Burgio, Gaetan; Foote, Simon
Description
Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/98412 |
Source: | Science |
DOI: | 10.1126/science.1228892 |
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01_McMorran_Platelet_factor_4_and_duffy_2012.pdf | 839.4 kB | Adobe PDF | Request a copy |
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