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Platelet factor 4 and duffy antigen required for platelet killing of Plasmodium falciparum

McMorran, Brendan; Wieczorski, Laura; Drysdale, Karen; Chan, Jo-Anne; Huang, Hong Ming; Smith, Clare; Mitiku, Chalachew; Beeson, James G; Burgio, Gaetan; Foote, Simon


Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Science
DOI: 10.1126/science.1228892


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