McMorran, Brendan; Wieczorski, Laura; Drysdale, Karen; Chan, Jo-Anne; Huang, Hong Ming; Smith, Clare; Mitiku, Chalachew; Beeson, James G; Burgio, Gaetan; Foote, Simon
Platelets restrict the growth of intraerythrocytic malaria parasites by binding to parasitized cells and killing the parasite within. Here, we show that the platelet molecule platelet factor 4 (PF4 or CXCL4) and the erythrocyte Duffy-antigen receptor (Fy) are necessary for platelet-mediated killing of Plasmodium falciparum parasites. PF4 is released by platelets on contact with parasitized red cells, and the protein directly kills intraerythrocytic parasites. This function for PF4 is critically...[Show more]
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