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Comparative analyses of developmental transcription factor repertoires in sponges reveal unexpected complexity of the earliest animals

Fortunato, Sofia; Adamski, Marchin; Adamska, Maja

Description

Developmental transcription factors (DTFs) control development of animals by affecting expression of target genes, some of which are transcription factors themselves. In bilaterians and cnidarians, conserved DTFs are involved in homologous processes such as gastrulation or specification of neurons. The genome of Amphimedon queenslandica, the first sponge to be sequenced, revealed that only a fraction of these conserved DTF families are present in demosponges. This finding was in line with the...[Show more]

dc.contributor.authorFortunato, Sofia
dc.contributor.authorAdamski, Marchin
dc.contributor.authorAdamska, Maja
dc.date.accessioned2016-02-24T22:40:37Z
dc.identifier.issn1874-7787
dc.identifier.urihttp://hdl.handle.net/1885/98385
dc.description.abstractDevelopmental transcription factors (DTFs) control development of animals by affecting expression of target genes, some of which are transcription factors themselves. In bilaterians and cnidarians, conserved DTFs are involved in homologous processes such as gastrulation or specification of neurons. The genome of Amphimedon queenslandica, the first sponge to be sequenced, revealed that only a fraction of these conserved DTF families are present in demosponges. This finding was in line with the view that morphological complexity in the animal lineage correlates with developmental toolkit complexity. However, as the phylum Porifera is very diverse, Amphimedon's genome may not be representative of all sponges. The recently sequenced genomes of calcareous sponges Sycon ciliatum and Leucosolenia complicata allowed investigations of DTFs in a sponge lineage evolutionarily distant from demosponges. Surprisingly, the phylogenetic analyses of identified DTFs revealed striking differences between the calcareous sponges and Amphimedon. As these differences appear to be a result of independent gene loss events in the two sponge lineages, the last common ancestor of sponges had to possess a much more diverse repertoire of DTFs than extant sponges. Developmental expression of sponge homologs of genes involved in specification of the Bilaterian endomesoderm and the neurosensory cells suggests that roles of many DTFs date back to the last common ancestor of all animals. Strikingly, even DTFs displaying apparent pan-metazoan conservation of sequence and function are not immune to being lost from individual species genomes. The quest for a comprehensive picture of the developmental toolkit in the last common metazoan ancestor is thus greatly benefitting from the increasing accessibility of sequencing, allowing comparisons of multiple genomes within each phylum.
dc.publisherElsevier BV
dc.sourceMarine Genomics
dc.titleComparative analyses of developmental transcription factor repertoires in sponges reveal unexpected complexity of the earliest animals
dc.typeJournal article
local.description.notesImported from ARIES
dc.date.issued2015
local.identifier.absfor060101 - Analytical Biochemistry
local.identifier.ariespublicationa383154xPUB3211
local.type.statusPublished Version
local.contributor.affiliationFortunato, Sofia, Sars International Centre for Marine Molecular Biology
local.contributor.affiliationAdamski, Marchin, Sars International Centre for Marine Molecular Biology
local.contributor.affiliationAdamska, Maja, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.identifier.doi10.1016/j.margen.2015.07.008
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2016-02-24T08:07:14Z
local.identifier.scopusID2-s2.0-84938651674
CollectionsANU Research Publications

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