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Chronic administration of anticonvulsants but not antidepressants impairs bone strength: Clinical implications

Gold, Philip W; Pavlatou, M G; Michelson, D; Mouro, CM; Kling, MA; Wong, Ma-Li; Licinio, Julio; Goldstein, SA


Major depression and bipolar disorder are associated with decreased bone mineral density (BMD). Antidepressants such as imipramine (IMIP) and specific serotonin reuptake inhibitors (SSRIs) have been implicated in reduced BMD and/or fracture in older depressed patients. Moreover, anticonvulsants such as valproate (VAL) and carbamazepine (CBZ) are also known to increase fracture rates. Although BMD is a predictor of susceptibility to fracture, bone strength is a more sensitive predictor. We...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Translational Psychiatry
DOI: 10.1038/tp.2015.38


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