Skip navigation
Skip navigation

Chronic administration of anticonvulsants but not antidepressants impairs bone strength: Clinical implications

Gold, Philip W; Pavlatou, M G; Michelson, D; Mouro, CM; Kling, MA; Wong, Ma-Li; Licinio, Julio; Goldstein, SA

Description

Major depression and bipolar disorder are associated with decreased bone mineral density (BMD). Antidepressants such as imipramine (IMIP) and specific serotonin reuptake inhibitors (SSRIs) have been implicated in reduced BMD and/or fracture in older depressed patients. Moreover, anticonvulsants such as valproate (VAL) and carbamazepine (CBZ) are also known to increase fracture rates. Although BMD is a predictor of susceptibility to fracture, bone strength is a more sensitive predictor. We...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/98361
Source: Translational Psychiatry
DOI: 10.1038/tp.2015.38

Download

File Description SizeFormat Image
01_Gold_Chronic_administration_of_2015.pdf619.38 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator