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Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-Infected african adults

MacLennan, Calman A.; Gilchrist, James J.; Gordon, Melita A.; Cunningham, Adam F; Cobbold, Mark; Goodall, Margaret; Kingsley, Robert A.; van Oosterhout, Joep J. G.; Msefula, Chisomo L.; Mandala, Wilson L.; Leyton, Denisse; Marshall, Jennifer; Gondwe, Esther N.; Bobat, Saeeda; Lopez-Macias, Constantino; Doffinger, Rainer; Henderson, Ian R; Zijlstra, Eduard E.; Dougan, Gordon; Drayson, Mark T.; MacLennan, Ian C M; Molyneux, Malcolm


Nontyphoidal Salmonellae are a major cause of life-threatening bacteremia among HIV-infected individuals. Although cell-mediated immunity controls intracellular infection, antibodies protect against Salmonella bacteremia. We report that high-titer antibodies specific for Salmonella lipopolysaccharide (LPS) are associated with a lack of Solmonella-killing in HIV-infected African adults. Killing was restored by genetically shortening LPS from the target Salmonella or removing LPS-specific...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Science
DOI: 10.1126/science.1180346


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