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Expression of human ARGONAUTE 2 inhibits endogenous microRNA activity in Arabidopsis

Deveson, Ira; Li, Junyan; Millar, Anthony A.


Plant and animal microRNA (miRNA) pathways share many analogous components, the ARGONAUTE (AGO) proteins being foremost among them. We sought to ascertain the degree of functional conservation shared by Homo sapiens ARGONAUTE 2 (HsAGO2) and Arabidopsis thaliana ARGONAUTE 1 (AtAGO1), which are the predominant AGO family members involved with miRNA activity in their respective species. Transgenic Arabidopsis plants expressing HsAGO2 were indistinguishable from counterparts over-expressing AtAGO1,...[Show more]

CollectionsANU Research Publications
Date published: 2013-04-13
Type: Journal article
Source: Frontiers in Plant Science
DOI: 10.3389/fpls.2013.00096


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