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Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?

Sutcliffe, Elissa L.; Li, Jasmine; Zafar, Anjum; Hardy, Kristine; Ghildyal, Reena; McCuaig, Robert; Norris, Nicole; Lim, Pek Siew; Milburn, Peter J.; Casarotto, Marco; Denyer, Gareth; Rao, Sudha


We recently provided the first description of a nuclear mechanism used by Protein Kinase C-theta (PKC-θ) to mediate T cell gene expression. In this mode, PKC-θ tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LSD1, and the adaptor molecule 14-3-3ζ at regulatory regions of inducible immune response genes. Moreover, our genome-wide analysis identified many novel PKC-θ target genes and...[Show more]

CollectionsANU Research Publications
Date published: 2012-08-28
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2012.00260


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