Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?
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Sutcliffe, Elissa L.; Li, Jasmine; Zafar, Anjum; Hardy, Kristine; Ghildyal, Reena; McCuaig, Robert; Norris, Nicole; Lim, Pek Siew; Milburn, Peter J.; Casarotto, Marco; Denyer, Gareth; Rao, Sudha
Description
We recently provided the first description of a nuclear mechanism used by Protein Kinase C-theta (PKC-θ) to mediate T cell gene expression. In this mode, PKC-θ tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LSD1, and the adaptor molecule 14-3-3ζ at regulatory regions of inducible immune response genes. Moreover, our genome-wide analysis identified many novel PKC-θ target genes and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012-08-28 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/97974 |
Source: | Frontiers in Immunology |
DOI: | 10.3389/fimmu.2012.00260 |
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01_Sutcliffe_Chromatinized_Protein_Kinase_2012.pdf | Published Version | 3.13 MB | Adobe PDF |
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