Chromatinized Protein Kinase C-θ: Can It Escape the Clutches of NF-κB?
We recently provided the first description of a nuclear mechanism used by Protein Kinase C-theta (PKC-θ) to mediate T cell gene expression. In this mode, PKC-θ tethers to chromatin to form an active nuclear complex by interacting with proteins including RNA polymerase II, the histone kinase MSK-1, the demethylase LSD1, and the adaptor molecule 14-3-3ζ at regulatory regions of inducible immune response genes. Moreover, our genome-wide analysis identified many novel PKC-θ target genes and...[Show more]
|Collections||ANU Research Publications|
|Source:||Frontiers in Immunology|
|01_Sutcliffe_Chromatinized_Protein_Kinase_2012.pdf||Published Version||3.13 MB||Adobe PDF|
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