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Dysregulation of the basal RNA polymerase transcription apparatus in cancer

Bywater, Megan J.; Pearson, Richard B.; McArthur, Grant A.; Hannan, Ross D.


Mutations that directly affect transcription by RNA polymerases rank among the most central mediators of malignant transformation, but the frequency of new anticancer drugs that selectively target defective transcription apparatus entering the clinic has been limited. This is because targeting the large protein-protein and protein-DNA interfaces that control both generic and selective aspects of RNA polymerase transcription has proved extremely difficult. However, recent technological advances...[Show more]

CollectionsANU Research Publications
Date published: 2013-05
Type: Journal article
Source: Nature Reviews Cancer
DOI: 10.1038/nrc3496


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