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Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

Mitchell, N. C.; Johanson, T. M.; Cranna, N. J.; Er, A. L. J.; Richardson, H. E.; Hannan, R. D.; Quinn, L. M.

Description

An unresolved question regarding the RNA-recognition motif (RRM) protein Half pint (Hfp) has been whether its tumour suppressor behaviour occurs by a transcriptional mechanism or via effects on splicing. The data presented here demonstrate that Hfp achieves cell cycle inhibition via an essential role in the repression of Drosophila myc (dmyc) transcription. We demonstrate that regulation of dmyc requires interaction between the transcriptional repressor Hfp and the DNA helicase subunit of...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/96949
Source: Development
DOI: 10.1242/dev.049585

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