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Cellular regulation of ribosomal DNA transcription:both rat and Xenopus UBF1 stimulate rDNA transcription in 3T3 fibroblasts

Hannan, R; Stefanovsky, V; Arino, T; Rothblum, L; Moss, T

Description

A novel RNA polymerase I (RPI) driven reporter gene has been used to investigate the in vivo role of the architectural ribosomal transcription factor UBF in gene activation and species specificity. It is shown that the level of UBF overexpression in NIH3T3 cells leads to a proportionate increase in the activities of both reporter and endogenous ribosomal genes. Further, co-expression of UBF antisense RNA suppresses reporter gene expression. Thus, UBF is limiting for ribosomal transcription in...[Show more]

CollectionsANU Research Publications
Date published: 1999-02-15
Type: Journal article
URI: http://hdl.handle.net/1885/96948
Source: Nucleic acids research
DOI: 10.1093/nar/27.4.1205

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