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ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

Wong, L. H.; McGhie, J. D.; Sim, M.; Anderson, M. A.; Ahn, S.; Hannan, R. D.; George, A. J.; Morgan, K. A.; Mann, J. R.; Choo, K.H. A.


ATRX (alpha thalassemia/mental retardation syndrome X-linked) belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain at its C terminus, it contains a PHD-like zinc finger at the N terminus. Mutations in the ATRX gene are associated with X-linked mental retardation (XLMR) often accompanied by alpha thalassemia (ATRX syndrome). Although ATRX has been postulated to be a transcriptional regulator, its precise roles remain undefined. We demonstrate ATRX...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Genome Research
DOI: 10.1101/gr.101477.109


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