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Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere

Wong, Lee H; Brettingham-Moore, Kate H; Chan, Lyn; Quach, Julie M; Anderson, Melissa A; Northrop, Emma L; Hannan, Ross; Saffery, Richard; Shaw, Margaret L; Williams, Evan; Choo, K H Andy

Description

The centromere is a complex structure, the components and assembly pathway of which remain inadequately defined. Here, we demonstrate that centromeric alpha-satellite RNA and proteins CENPC1 and INCENP accumulate in the human interphase nucleolus in an RNA polymerase I-dependent manner. The nucleolar targeting of CENPC1 and INCENP requires alpha-satellite RNA, as evident from the delocalization of both proteins from the nucleolus in RNase-treated cells, and the nucleolar relocalization of these...[Show more]

CollectionsANU Research Publications
Date published: 2007-08
Type: Journal article
URI: http://hdl.handle.net/1885/96945
Source: Genome research
DOI: 10.1101/gr.6022807

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