Wong, Lee H; Brettingham-Moore, Kate H; Chan, Lyn; Quach, Julie M; Anderson, Melissa A; Northrop, Emma L; Hannan, Ross; Saffery, Richard; Shaw, Margaret L; Williams, Evan; Choo, K H Andy
The centromere is a complex structure, the components and assembly pathway of which remain inadequately defined. Here, we demonstrate that centromeric alpha-satellite RNA and proteins CENPC1 and INCENP accumulate in the human interphase nucleolus in an RNA polymerase I-dependent manner. The nucleolar targeting of CENPC1 and INCENP requires alpha-satellite RNA, as evident from the delocalization of both proteins from the nucleolus in RNase-treated cells, and the nucleolar relocalization of these...[Show more]
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