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A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation

George, A. J.; Purdue, B. W.; Gould, C. M.; Thomas, D. W.; Handoko, Y.; Qian, H.; Quaife-Ryan, G. A.; Morgan, K. A.; Simpson, K. J.; Thomas, W. G.; Hannan, R. D.


The angiotensin type 1 receptor (AT1R) transactivates the epidermal growth factor receptor (EGFR) to mediate cellular growth, however, the molecular mechanisms involved have not yet been resolved. To address this, we performed a functional siRNA screen of the human kinome in human mammary epithelial cells that demonstrate a robust AT1R-EGFR transactivation. We identified a suite of genes encoding proteins that both positively and negatively regulate AT1R-EGFR transactivation. Many candidates...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.128280


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