Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models
Lee, Jue Er Amanda; Mitchell, Naomi C.; Zaytseva, Olga; Chahal, Arjun; Mendis, Peter; Cartier-Michaud, Amandine; Parsons, Linda M.; Poortinga, Gretchen; Levens, David L.; Hannan, Ross D.; Quinn, Leonie M.
Nucleotide excision DNA repair (NER) pathway mutations cause neurodegenerative and progeroid disorders (xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD)), which are inexplicably associated with (XP) or without (CS/TTD) cancer. Moreover, cancer progression occurs in certain patients, but not others, with similar C-terminal mutations in the XPB helicase subunit of transcription and NER factor TFIIH. Mechanisms driving overproliferation and, therefore, cancer...[Show more]
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