The synthesis and breakdown of phosphocreatine in animal tissues : a study of creatine phosphokinase
Nearly half a century ago the element phosphorus was introduced into biochemistry with the observation of Harden and Young (1905) that inorganic phosphate added to fermenting yeast could not, after a time, be precipitated with either magnesia mixture or silver nitrate. The subsequent work of Harden and Young (1906, 1908) produced evidence that the phosphate was esterified and largely appeared in a form of hexose phosphate. At that time the compound was considered to be merely a by-product of...[Show more]
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