Emerging targets in human lymphoma: targeting the MYD88 mutation
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Wang, James Q.; Jeelall, Yogesh S.; Horikawa, Keisuke
Description
B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013-08-13 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/95819 |
Source: | Blood and Lymphatic Cancer: Targets and Therapy |
DOI: | 10.2147/BLCTT.S35292 |
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01_Jeelall_Emerging_targets_in_human_2013.pdf | Published Version | 314.74 kB | Adobe PDF |
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