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Emerging targets in human lymphoma: targeting the MYD88 mutation

Wang, James Q.; Jeelall, Yogesh S.; Horikawa, Keisuke


B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid...[Show more]

CollectionsANU Research Publications
Date published: 2013-08-13
Type: Journal article
Source: Blood and Lymphatic Cancer: Targets and Therapy
DOI: 10.2147/BLCTT.S35292


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