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Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Devlin, J. R.; Hannan, Katherine; Hein, Nadine; Cullinane, C.; Kusnadi, E.; Ng, P. Y.; George, A. J.; Shortt, J.; Bywater, M. J.; Poortinga, G.; Sanij, E.; Kang, J.; Drygin, D.; O'Brien, S.; Johnstone, R. W.; McArthur, G. A.; Hannan, R. D.; Pearson, R. B.

Description

UNLABELLED Ribosome biogenesis and protein synthesis are dysregulated in many cancers, with those driven by the proto-oncogene c-MYC characterized by elevated Pol I-mediated ribosomal rDNA transcription and mTORC1/eIF4E-driven mRNA translation. Here, we demonstrate that coordinated targeting of rDNA transcription and PI3K-AKT-mTORC1-dependent ribosome biogenesis and protein synthesis provides a remarkable improvement in survival in MYC-driven B lymphoma. Combining an inhibitor of rDNA...[Show more]

CollectionsANU Research Publications
Date published: 2015-10-21
Type: Journal article
URI: http://hdl.handle.net/1885/95658
Source: Cancer Discovery
DOI: 10.1158/2159-8290.CD-14-0673
Access Rights: Open Access

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