Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells
Diesch, Jeannine; Sanij, Elaine; Gilan, Omer; Love, Christopher; Tran, Hoanh; Fleming, Nicholas I.; Ellul, Jason; Amalia, Marcia; Haviv, Izhak; Pearson, Richard B.; Tulchinsky, Eugene; Mariadason, John M.; Sieber, Oliver M.; Hannan, Ross D.; Dhillon, Amardeep S.
Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 family transcription factor FRA1, a potent regulator of migration and invasion in a variety of tumor cell types. However, the nature of FRA1 transcriptional targets and the molecular pathways through which they promote tumor progression remain...[Show more]
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