Drosophila Ribosomal Protein Mutants Control Tissue Growth Non-Autonomously via Effects on the Prothoracic Gland and Ecdysone
Lin, Jane I.; Mitchell, Naomi C.; Kalcina, Marina; Tchoubrieva, Elly; Stewart, Mary J.; Marygold, Steven J.; Walker, Cherryl D.; Thomas, George; Leevers, Sally J.; Pearson, Richard B.; Quinn, Leonie M.; Hannan, Ross D.
The ribosome is critical for all aspects of cell growth due to its essential role in protein synthesis. Paradoxically, many Ribosomal proteins (Rps) act as tumour suppressors in Drosophila and vertebrates. To examine how reductions in Rps could lead to tissue overgrowth, we took advantage of the observation that an RpS6 mutant dominantly suppresses the small rough eye phenotype in a cyclin E hypomorphic mutant (cycE(JP)). We demonstrated that the suppression of cycE(JP) by the RpS6 mutant is...[Show more]
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