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Proffered Paper: Inhibition of RNA Polymerase I transcription by CX-5461 as a completely new approach to treat highly refractory haematological malignancies

Hannan, R.; Hein, Nadine; O’Brien, S. E.; Drygin, D.; Cullinane, C.; Matthews, G.; Johnstone, R.W.; Pearson, R.B.; McArthur, G.; Harrison, S.

Description

Recent findings by our group have been instrumental in the development of the novel selective inhibitor of RNA Polymerase I (Pol I), CX-5461 (Drygin et al., Cancer Research, 2011; Bywater et al. Cancer Cell, 2012). This work has led to the fundamental discovery that ribosomal gene transcription by Pol I is not simply a ‘house keeping’ process in cancer cells but is highly regulated to maintain their viability (Bywater et al., Nature Reviews Cancer 2013). Strikingly, inhibition of Pol I...[Show more]

CollectionsANU Research Publications
Date published: 2014-07
Type: Conference paper
URI: http://hdl.handle.net/1885/95633
Source: European Journal of Cancer: 23rd Biennial Congress of the European Association for Cancer Research, 5–8 July 2014, Munich, Germany
DOI: 10.1016/S0959-8049(14)50070-6

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