Targeting MYC-driven growth and proliferation in prostate cancer
Over the last decade, the oncogene MYC has emerged as a key driver of survival, growth and proliferation in prostate cancer. The transforming activity of this potent oncogene partly depends on its ability to modulate RNA Pol I transcription activity which is required for ribosome synthesis. Considering that cancer cells are dependent on high rates of RNA Pol I transcription, we explored the efficacy of targeting PolI transcription with a small molecule inhibitor in prostate cancer.
|Collections||ANU Research Publications|
|Source:||European Journal of Cancer|
|1-s2.0-S0959804914506764-main.pdf||Conference abstract||65.53 kB||Adobe PDF|
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