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Targeting MYC-driven growth and proliferation in prostate cancer

Rebello, R.; Drygin, D.; Cameron, D.; Risbridger, G.P.; Pearson, R.B.; Hannan, R.D.; Furic, L.

Description

Over the last decade, the oncogene MYC has emerged as a key driver of survival, growth and proliferation in prostate cancer. The transforming activity of this potent oncogene partly depends on its ability to modulate RNA Pol I transcription activity which is required for ribosome synthesis. Considering that cancer cells are dependent on high rates of RNA Pol I transcription, we explored the efficacy of targeting PolI transcription with a small molecule inhibitor in prostate cancer.

CollectionsANU Research Publications
Date published: 2014-07
Type: Conference poster
URI: http://hdl.handle.net/1885/95632
Source: European Journal of Cancer
DOI: 10.1016/S0959-8049(14)50676-4

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