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Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis

Zimmermann, N.; King, Nina E.; Laporte, Johanne; Yang, Ming; Mishra, Anil; Pope, Sam M.; Muntel, Emily E.; Witte, David P.; Pegg, Anthony A.; Foster, Paul S.; Hamid, Qutayba; Rothenberg, Marc E.


Asthma is on the rise despite intense, ongoing research underscoring the need for new scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an approach involving expression profiling of lung tissue from mice with experimental asthma. Employing asthma models induced by different allergens and protocols, we identified 6.5% of the tested genome whose expression was altered in an asthmatic lung. Notably, two phenotypically similar models of experimental...[Show more]

CollectionsANU Research Publications
Date published: 2003-06-15
Type: Journal article
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI200317912


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