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Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice

Dunphy, Karen A; Blackburn, Anneke C; Yan, Haoheng; O'Connell, Lauren R; Jerry, D Joseph


INTRODUCTION Treatment with estrogen and progesterone (E+P) mimics the protective effect of parity on mammary tumors in rodents and depends upon the activity of p53. The following experiments tested whether exogenous E+P primes p53 to be more responsive to DNA damage and whether these pathways confer resistance to mammary tumors in a mouse model of Li-Fraumeni syndrome. METHODS Mice that differ in p53 status (Trp53+/+, Trp53+/-, Trp53-/-) were treated with E+P for 14 days and then were tested...[Show more]

CollectionsANU Research Publications
Date published: 2008-05-12
Type: Journal article
Source: Breast Cancer Research
DOI: 10.1186/bcr2094


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