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Antinociceptive action of oxytocin involves inhibition of potassium channel currents in lamina II neurons of the rat spinal cord

Breton, Jean; Poisbeau, Pierrick; Darbon, Pascal


BACKGROUND Growing evidence in the literature shows that oxytocin (OT) has a strong spinal anti-nociceptive action. Oxytocinergic axons originating from a subpopulation of paraventricular hypothalamic neurons establish synaptic contacts with lamina II interneurons but little is known about the functional role of OT with respect to neuronal firing and excitability. RESULTS Using the patch-clamp technique, we have recorded lamina II interneurons in acute transverse lumbar spinal cord slices of...[Show more]

CollectionsANU Research Publications
Date published: 2009-11-12
Type: Journal article
Source: Molecular Pain
DOI: 10.1186/1744-8069-5-63


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